GS - 441524 and Mutian Cure FIP! Happy New Year!

The Holy Grail

I first read about it on a private website. As usual the FDA is a stumbling block so private Asian manufacturers have stepped in to bring the cure within our reach instead of sitting on it while our cats suffer. Please go straight to the websites without further delay if your cat needs treatment. The interesting in depth story can wait. 

Anti viral pro drug GS 441524

 treatment of choice as per Dr Adie. Available from https://www.curefip.com/ 

"Dose: GS-441524 treatment at a dosage of 4 mg/kg SC sid for at least 12 weeks, repeating the course if clinical signs recur. The dose can be safely increased to 5mg/kg Murphy et al., 2018 in severe cases and 10mg/kg in ocular cases.
In the field study, about one third of the cats required subsequent courses of treatment and one cat appeared to have a virus which was resistant to the drug.
Remember that this treatment would be off label and that you should have your client sign your practice's legal disclaimer form. There is no veterinary preparation yet available: one awaits news from Gilead Sciences, CA, USA. Check with your own regulatory body for advice about the legality of its use in your own country.
Side effects: the treatment stings on administration and injection site reactions occurred in 16 of 26 cats treated. (Injection site reactions are worrisome in cats, because they can lead to fibrosarcoma formation.) However, no other toxic side effects have been reported so far, in fact, Dr Pedersen stated that it was "remarkably safe". (Pedersen et al, 2019)
GS-441524 not working in your patient?
In my experience, the main reason for this is that the cat is not, in fact, suffering from FIP: 40% of the cats referred to me - usually from referral practices - have had some disease other than FIP." - Dr Adie

Mutian X 

https://www.mutianstore.com/blogs/mutian-warriors has live chat which will provide targeted advice free for your cat

"
Mutian X is available as tablets / capsules or injections. Their CEO informs me that it has FDA approval.Their website is www.mutian.us.Mutian X pills are effective at stopping FCoV shedding: the dose for clearing FCoV infection is 4mg/kg for four days.I am only aware of a couple of cats with FIP who are being treated using Mutian X: watch this space for updates. Liver support using S-adenosyl-L-methionine is essential for longer term use with this compound." Dr  Adie

Happy new year indeed!

Dr Adie's website is http://www.catvirus.com/treatment.htm

Seeing clearly - Dr Ray Peat on Stress

The transparency of life

Information for humans by Dr Ray Peat who taught physiology to medical students for many years. He follows a bioenergetic way of thinking about health and disease processes.

Diseases that produce tissue overgrowth associated with inflammation--granulomas--have been treated with iodides, and although the iodide doesn’t necessarily kill the germ, it does help to break down and remove the granuloma.

Leprosy and syphilis were among the diseases involving granulomas* that were treated in this way. In the case of tuberculosis, it has been suggested that iodides combine with unsaturated fatty acids which inhibit proteolytic enzymes, and thus allow for the removal of the abnormal tissue.

In experimental animals, iodide clearly delays the appearance of cataracts. (Buchberger, et al., 199l.)
raypeat.com/articles/aging/transparency-cataracts.shtml

Gelatin, stress, longevity

The amino acids cysteine and tryptophan, released in large quantities during stress, have antimetabolic (thyroid-suppressing) and, eventually, toxic effects  

A generous supply of glycine/gelatin, against a balanced background of amino acids, has a great variety of antistress actions. Glycine is recognized as an “inhibitory” neurotransmitter, and promotes natural sleep. Used as a supplement, it has helped to promote recovery from strokes and seizures, and to improve learning and memory. But in every type of cell, it apparently has the same kind of quieting, protective antistress action. The range of injuries produced by an excess of tryptophan and serotonin seems to be prevented or corrected by a generous supply of glycine. Fibrosis, free radical damage, inflammation, cell death from ATP depletion or calcium overload, mitochondrial damage, diabetes, etc., can be prevented or alleviated by glycine.

Some types of cell damage are prevented almost as well by alanine and proline as by glycine, so the use of gelatin, rather than glycine, is preferable, especially when the gelatin is associated with its normal biochemicals. For example, skin is a rich source of steroid hormones, and cartilage contains “Mead acid,” which is itself antiinflammatory

 http://raypeat.com/articles/articles/gelatin.shtml

Tank

Dry FIP

Here's a story i was sent about a Bengal calked Tank who had dry FIP. He was treated with Polyprenyl immunostimulant PI. Best Therapy option back in the days before GS 441524 I guess i never published it as i was waiting to see the outcome.

His blood work indicated liver damage with high globulins, his A/G ratio was 0.5, his ALT and bilirubin were high and he was borderline low I took him to a specialist for an ultrasound, liver biopsy, fine needle aspirate of some excess fluids in his abdomen (the internist said it was more "free floating abdominal fluids then you normally see in a kitten), second blood chemistry panel. The results were liver inflammation, fluids consistent with what you would find in FIP (high protein, high neutrophils, etc.), his A/G ratio had gone down, his liver biopsy rules out copper storage disease, his toxo test came back negative. So for all intents and purposes, there is no other disease that this could be. 
I had already put him on 3 times weekly PI (Feb. 22 after his first vet visit) and then upped it to daily based on a conversation I had with Dr. Sass who said when it's really bad - use it daily. I thought this deserved daily treatment I added Denamarin which supposedly prevents further cell damage to the liver and helps the liver heal itself. Then he also was put on Clindamycin for one month - just in case the toxo test produced a false negative, but given the extremely slow recover - it's fair to say it's not toxo. In toxo upon administration of Clindamycin, the recovery is dramatic.

 March 26

Thought that I'd post an update on Tank. He's been on daily PI for about nine days now. He's been on Denamarin (liver support supplement) for four days and on Clindamycin for nine days as well. He has gained 1/2 lbs in the last five days. He's gone back to grooming himself, eats like a horse and is back to wrecking my house as a "normal" Bengal kitten should. Cautiously optimistic that perhaps his FIP is going into remission. Blood work again in three weeks