Friday 17 January 2020

GS - 441524 and Mutian Cure FIP! Happy New Year!

The Holy Grail

I first read about it on a private website. As usual the FDA is a stumbling block so private Asian manufacturers have stepped in to bring the cure within our reach instead of sitting on it while our cats suffer. Please go straight to the websites without further delay if your cat needs treatment. The interesting in depth story can wait. 

Anti viral pro drug GS 441524

 treatment of choice as per Dr Adie. Available from https://www.curefip.com/ 
"Dose: GS-441524 treatment at a dosage of 4 mg/kg SC sid for at least 12 weeks, repeating the course if clinical signs recur. The dose can be safely increased to 5mg/kg Murphy et al., 2018 in severe cases and 10mg/kg in ocular cases.
In the field study, about one third of the cats required subsequent courses of treatment and one cat appeared to have a virus which was resistant to the drug.
Remember that this treatment would be off label and that you should have your client sign your practice's legal disclaimer form. There is no veterinary preparation yet available: one awaits news from Gilead Sciences, CA, USA. Check with your own regulatory body for advice about the legality of its use in your own country.
Side effects: the treatment stings on administration and injection site reactions occurred in 16 of 26 cats treated. (Injection site reactions are worrisome in cats, because they can lead to fibrosarcoma formation.) However, no other toxic side effects have been reported so far, in fact, Dr Pedersen stated that it was "remarkably safe". (Pedersen et al, 2019)
GS-441524 not working in your patient?
In my experience, the main reason for this is that the cat is not, in fact, suffering from FIP: 40% of the cats referred to me - usually from referral practices - have had some disease other than FIP." - Dr Adie
Mutian X 

https://www.mutianstore.com/blogs/mutian-warriors has live chat which will provide targeted advice free for your cat
"
Mutian X is available as tablets / capsules or injections. Their CEO informs me that it has FDA approval.Their website is www.mutian.us.Mutian X pills are effective at stopping FCoV shedding: the dose for clearing FCoV infection is 4mg/kg for four days.I am only aware of a couple of cats with FIP who are being treated using Mutian X: watch this space for updates. Liver support using S-adenosyl-L-methionine is essential for longer term use with this compound." Dr  Adie
Happy new year indeed!

Dr Adie's website is http://www.catvirus.com/treatment.htm

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