Sunday, 4 October 2020

COVID19 in Cats - the Ivermectin treatment

I just thought i'd bring this to your attention in case the authorities ever decide to start freaking out about pets transmitting covid19 . We have seen several cases expressed in the news for companion animals and the culling of mink in the netherlands. But the researchers are still dancing around trying not to alarm anyone. China led the studies with cats in april. Cats are quarantined and swabbed in covid positive households in hongkong. 

Here's the update from Dr Niels C Pedersen on the situation - i think he's got it backwards and we should urgently hose down the companion animal reservoir of coronaviruses. Healthy companion animals make more sense surely than sickly ones even if we aren't eating them! ( i would hate to see a FIP like illness appear in humans! )

Dear Veterinarians, cat owners and public: I am being increasingly questioned about the relationship of GS-441524 and a very promising treatment for Covid-19, Remdesivir.  GS-441524 is the biologically active component of Remdesivir and has been widely used around the world to safely and effectively cure cats of feline infectious peritonitis (FIP) for over 18 months. FIP is a common and highly fatal coronavirus disease of cats. GS-441424 and Remdesivir are almost identical drugs. Remdesivir is the form of GS-441424 that Gilead Sciences has chosen to use in humans for COVID-19 and is now in clinical trials in China, USA and several other countries. Remdesivir is what is known as a prodrug. A prodrug is altered by infected cells to yield the active ingredient, which in this case is basically GS-441524 with the addition of one phosphate group (i.e., GS-5734).  Gilead scientists slightly altered GS-5734 to protect the added phosphate group and allow absorption into cells. This form of GS-441524 is what is known as Remdesivir. Once in the cells, cellular enzymes remove the protection to yield  GS-5734. GS-5734 is further activated by the addition of two more phosphates in the cells to the triphosphate form of GS-441524. This is the molecule that inhibits the production of viral RNA.  We chose to use GS-441524 for treatment of the coronavirus disease FIP because it had identical antiviral properties to Remdesivir and at the time was not under consideration by Gilead Sciences for use in humans. GS-441524 is also much cheaper to make than Remdesivir. Therefore, there was no apparent conflict with using one form for cats and another form for humans.  However, Gilead came to believe that our cat research would interfere with their ability to get Remdesivir approved for humans and refused to grant animal rights for GS-441524.  This refusal, coupled with the desperate need around the world for the treatment of FIP, led to a Chinese black market for GS-441524.  FIP is also a significant problem in pet cats in China, and Chinese cat owners were even more desperate for a treatment for FIP than owners in other countries. The first papers describing GS-441524 treatment of cats with FIP were published in 2018 and 2019 and thousands of cats have been treated since then. In spite of this experience, the medical profession, including researchers, have been seemingly unaware of the use of GS-441524 for a coronavirus disease of cats and its relationship to Remdesivir. Veterinarians also have considerable experience with coronaviruses, coronavirus diseases, and coronavirus vaccines for swine, calves and poultry that has gone unappreciated. Pet ferrets also suffer a severe FIP-like disease caused by their own species of coronavirus.What will happen to supplies of GS-441524 for cats if Remdesivir is proven to be safe and effective as a treatment for Covid-19?  GS-441524 is the first critical step in the production of Remdesivir and it is logical to assume that there will be a competition between cats and humans for it.  On a positive note, world wide approval for Remdesivir may also help change minds against granting animal rights for GS-441524. If approved for human use, Remdesivir, if not GS-441524, would become "legally" available through veterinarians.  However, the safety and efficacy of Remdesivir for FIP has not been established. 

-Niels C. Pedersen, DVM, PhD, School of Veterinary Medicine, UC Davis. via 

Friday, 17 January 2020

GS - 441524 and Mutian Cure FIP! Happy New Year!

The Holy Grail

I first read about it on a private website. As usual the FDA is a stumbling block so private Asian manufacturers have stepped in to bring the cure within our reach instead of sitting on it while our cats suffer. Please go straight to the websites without further delay if your cat needs treatment. The interesting in depth story can wait. 

Anti viral pro drug GS 441524

 treatment of choice as per Dr Adie. Available from 
"Dose: GS-441524 treatment at a dosage of 4 mg/kg SC sid for at least 12 weeks, repeating the course if clinical signs recur. The dose can be safely increased to 5mg/kg Murphy et al., 2018 in severe cases and 10mg/kg in ocular cases.
In the field study, about one third of the cats required subsequent courses of treatment and one cat appeared to have a virus which was resistant to the drug.
Remember that this treatment would be off label and that you should have your client sign your practice's legal disclaimer form. There is no veterinary preparation yet available: one awaits news from Gilead Sciences, CA, USA. Check with your own regulatory body for advice about the legality of its use in your own country.
Side effects: the treatment stings on administration and injection site reactions occurred in 16 of 26 cats treated. (Injection site reactions are worrisome in cats, because they can lead to fibrosarcoma formation.) However, no other toxic side effects have been reported so far, in fact, Dr Pedersen stated that it was "remarkably safe". (Pedersen et al, 2019)
GS-441524 not working in your patient?
In my experience, the main reason for this is that the cat is not, in fact, suffering from FIP: 40% of the cats referred to me - usually from referral practices - have had some disease other than FIP." - Dr Adie
Mutian X has live chat which will provide targeted advice free for your cat
Mutian X is available as tablets / capsules or injections. Their CEO informs me that it has FDA approval.Their website is X pills are effective at stopping FCoV shedding: the dose for clearing FCoV infection is 4mg/kg for four days.I am only aware of a couple of cats with FIP who are being treated using Mutian X: watch this space for updates. Liver support using S-adenosyl-L-methionine is essential for longer term use with this compound." Dr  Adie
Happy new year indeed!

Dr Adie's website is

Seeing clearly - Dr Ray Peat on Stress

The transparency of life

Information for humans by Dr Ray Peat who taught physiology to medical students for many years. He follows a bioenergetic way of thinking about health and disease processes.
Diseases that produce tissue overgrowth associated with inflammation--granulomas--have been treated with iodides, and although the iodide doesn’t necessarily kill the germ, it does help to break down and remove the granuloma.
Leprosy and syphilis were among the diseases involving granulomas* that were treated in this way. In the case of tuberculosis, it has been suggested that iodides combine with unsaturated fatty acids which inhibit proteolytic enzymes, and thus allow for the removal of the abnormal tissue.
In experimental animals, iodide clearly delays the appearance of cataracts. (Buchberger, et al., 199l.)

Gelatin, stress, longevity

The amino acids cysteine and tryptophan, released in large quantities during stress, have antimetabolic (thyroid-suppressing) and, eventually, toxic effects  

A generous supply of glycine/gelatin, against a balanced background of amino acids, has a great variety of antistress actions. Glycine is recognized as an “inhibitory” neurotransmitter, and promotes natural sleep. Used as a supplement, it has helped to promote recovery from strokes and seizures, and to improve learning and memory. But in every type of cell, it apparently has the same kind of quieting, protective antistress action. The range of injuries produced by an excess of tryptophan and serotonin seems to be prevented or corrected by a generous supply of glycine. Fibrosis, free radical damage, inflammation, cell death from ATP depletion or calcium overload, mitochondrial damage, diabetes, etc., can be prevented or alleviated by glycine.
Some types of cell damage are prevented almost as well by alanine and proline as by glycine, so the use of gelatin, rather than glycine, is preferable, especially when the gelatin is associated with its normal biochemicals. For example, skin is a rich source of steroid hormones, and cartilage contains “Mead acid,” which is itself antiinflammatory