Pharoah tries stemcells for FIP and the cure for FIP is found!

One success story at a time

With FIP there is no point being conservative except for the sake of the cat's comfort. So it was no surprise to hear that yet another innovative therapy is being tried - adipose stemcell therapy for dry FIP. The cat is called Pharoah and his vet is Ed Pattison of City Vets, Exeter UK https://www.facebook.com/cityvets/photos/a.128542133823284.22418.128403317170499/957763074234515/

But how interesting is this - the vet who pioneered the use of adipose stemcells for arthritis in dogs in australia, Simon Craig, was the same chap who cured Dusty of wet FIP - see survivor's page

and how dull and unsexy is this - Hip arthritis in dogs by the way you can simply prevent with adequate vitamin C and a proper diet.
http://oneradionetwork.com/health/dr-r-geoffrey-broderick-world-renowned-veterinarian/

Dr Belfield has the word on vitamin c in animals and was kind enough to answer my emails when Mishka was diagnosed. he did try it for FIP of course and it was the one thing he had no success with after it was established :( That's what we are up against.
I have NO DOUBT this is the same with FIP - we can prevent it  simply - no rocket stemcell science required and finally someone in authority is brave enough to say it 

"The best treatment for FIP is not to get it in the first place: if you are going to buy a pedigree kitten, make sure your Vet sends a blood sample to the University of Glasgow Veterinary Diagnostic Services to get a certificate saying that the kitten tested negative for feline coronavirus (FCoV) antibodies: we need to put consumer pressure on bad breeders and reward good ones." Dr Dianne Addie rocks! http://www.theexeterdaily.co.uk/news/local-news/exeter-vets-pioneer-stem-cell-treatment

- see prevention page

• stop inbreeding 
• stop crowding 
• stop malnourishment of starvation and stop feeding COOKED CRAP & KIBBLE to cats - they weren't designed to eat cereal; they are not birds.

Murphy - misdiagnosis of wet FIP

Mischievous Murphy from Germany is a kitten successfully treated for bacterial peritonitis which was initially mis-diagnosed as FIP in April 2013 when he was 8 months old. Fortunately Jennifer did not give up. She found a second opinion from another vet, who although she could not rule out FIP even though his abdominal fluid tested negative for coronavirus, committed to save him and went for treating the treatable in the face of uncertainty. Murphy was given Suanatem (Metronidazole and Spiramycin) and recovered quickly.

This continues the series on misdiagnosis. Please make sure you check out Dr Addies's diagnostic algorithm's for FIP on treatment page before losing hope. And donate to FIP research which is working towards a fast and reliable diagnostic tool. In australia this is University of Sydney with Jaqui Norris.

Alfie

FIP is notoriously hard to diagnose if it is dry form - but even the wet form does have a differential.

Dear all,
Today we had to say goodbye to our 11 week old baby Alfie. 3 days ago he started to get sick; his appetite was gone, he was lethargic, I could feel his spine and ribs while his tummy felt "healthy" as if he just had eaten.

All these symptoms worried me, so I went with him to the vet the day after. They took blood samples to send to the lab. The abdominal puncture fluid was clear, colourless and not stringy.

The following day we got back the results from the lab and they were not consistent with fip. Today, we took him to a clinic for an ultrasound, a Rivalta test and an analysis of the puncture fluid. The Rivalta test was very clearly negative and through the ultrasound we learned Alfie had a congenital disorder; his pericardium contained not only his heart but also a big part of his liver... This is not a inherited disease but "just" something in the embryonic development that went wrong :(

Without surgery there was no chance for Alfie, so we didn't have a choice but to give him this chance and left him there for surgery later today. Unfortunately Alfie was already too weak or maybe just too young too cope with the anaesthetics and died even before the surgery could start. Obviously we are very sad about this...

For three days I lived with the sadness, stress and insecurity that a lot of you have been through too when you discover your kitten might have fip. I have been in contact with some of you and I searched the internet for information about fip and differential diagnosis while at the same time I was afraid to believe it could be anything else but the much dreaded fip... It's for this reason that I want to share Alfie's story. If you think your kitten might have (the beginning of) wet fip, insist on all the tests at once. Blood and puncture fluid analysis, Rivalta test and ultrasound of abdomen and thorax, because my Alfie is proof that this can give some of the symptoms presented by fip.

PS On the picture you can see Alfie in better days... We miss him so much :(

from Cattery SmittenKitten

Dr Pedersen's comments on expensive diagnostic tests

"Okay, I'm not going to do many graphic pictures, but I do not understand why veterinarians have so much trouble diagnosing it like me, okay. I do not understand it because there are just the two forms. There is the wet form and the dry form and sometimes there is a little intermediate as they can switch from one to another and you can catch them in that transition stage, but people seem to have a hard time making this diagnosis, and like Al said, if you have a young cat from a shelter cattery that has a distended abdomen and has this yellowish, mucinous fluid that contains the right kind of inflammatory cells, high protein… gee, what else is this? What else can we call it? And the problem that we have is that because the diagnosis of FIP as I said, once they become clinically apparent, they’re going to die, okay, and I tell you right now, they’re going to die. There is no treatment. Okay… that I know of, that has been successful to reverse this thing. Okay, so basically because it’s a fatal disease, people especially veterinarians, and especially owners and especially pathologists; do not want to tell you that this is a fatal disease. They say, just as Al says. You get tired of seeing a path report that describes, there's a clinical history just like FIP, lesions that cannot be anything but FIP and then they say, characteristic of FIP, typical FIP. What does that mean? You tell me, does it have FIP? Just tell me.

And so, the problem is that in any of these kinds of diseases where there is a 100% mortality and believe me, owners are just as guilty because owners will push that risk, and is there a chance that it is this, or it is that, toxoplasmosis is one million, you know, is it the mycosis, one in a million, you know, all of these things, and so, they are always grasping for stuff and they are pushing it, and the more they push you, the more diagnostic tests that you ask for, and the problem is that hardly any of those diagnostic tests are 100% correct. And so, even the PCR test maybe only 80%. Immunohistochemistry might be 70-80% depending on what you do. The blood work is not 100%. They are all just little things that help you make the diagnosis, but there is not a single test that’s simple, short of taking a biopsy or taking some fluid, and doing a specific test by a lab that knows what they are doing, which is another problem, okay, to get a decent result back. And then, you know, then there are still veterinarians refusing to believe that antibody titers are not necessarily diagnostic, so they will continue to do the FIP virus serology on a whole bunch of cats. One cat will die of FIP in the cattery. They will test every cat for $30 or $40 a cat, and then they’ll get the results back and then they will say, “Well, I don’t know what they mean.” So then they’ll call me up. Well, I didn’t order 50 serologies at $50 a piece, you know, and so they wanted a free consult, you know, as far as I never charge for consults, but they want a consultation as to what that test means, well, no veterinarian should ever ask for a test that they do not know how to interpret it.
If the results come back [Applause] if the results come back and they can’t interpret it, why the hell did they ask for it in the first place?"  from WINN feline foundation 2011 FIP symposium

The Christmas Tomten

“Winters come and winters go, Summers come and summers go, Soon the swallows will be here.” thinks the Tomten.

Yuletide "the midpoint of winter - the cosmic balance between life and death". I feel like we are poised on such a tipping point - and i cant help thinking being in the southern hemisphere the december solstice signals the descent.

Mishka has been going 4 months on the FIP roller coaster. She's on Feline interferon twice a week and a weekly abdo drainage and one week into a trial of PI to see if we can tip the balance over toward life.

There are a few other kittens diagnosed around the same time still alive and well including Tomten - who is named after a scandinavian gnome who talks to the cat in tomten language, "a silent little language a cat can understand."

Nov 2012 "Our biggest fear in the storm was how to keep the feline interferon cold when we lost power. (My vet is importing it from the UK). Jan 1 will be the six month mark so we are thinking about doing another ultrasound then to see how everything looks. Knock on wood Gizmo also seems ok. Not sure how Gizmo would ever handle it if we loose Tom as they are inseparable." ~ Cassie

Gizmo and Tomten, the darker kitty who has FIP, live with the Hallbergs in New Jersey USA. He was diagnosed back in July 2012. His mom Cassie posts updates to the FIPcat support yahoo group. In october his dosages were prednisone 2mg daily and Feline Interferon injections .4ml weekly. Now it is down to every 2nd day for the prednisone and every ten days for the interferon.

Good Yule Tomten and family! Here is a video interpretation of the children's book 'The Tomten' to enjoy http://www.youtube.com/watch?v=ABMDcIJp784

Wednesday, December 12, 2012

Hi everyone- sorry its been a while since I posted. Hurricane Sandy did a number on our internet.

Tomten continues to do well. He will be at the 6 month mark since his initial diagnosis on Jan 1st 2012 (Big Day!!!) So for everyone who is new to this site and feeling at a total loss (That was me 6 months ago) there is hope!

For the most part he continues to do well. He is now on the feline interferon injections once every 10 days plus Prednisone every other day. The last two weeks he was a bit withdrawn and less active but the last two days he seems back to himself. (we live in total dread when his behavior changes the least little bit)

I took him and his brother Gizmo for their annual check up last Saturday. His regular vet (he also sees an internal medicine specialist who is leading the FIP treatment) was amazed by him. We decided to never vaccinate him again so as not to stress his immune system. She also took some blood to run a blood pannel. Both Vets agree that they want to rescan him again in January to see if the intestinal mass is still gone and if the lymph nodes are still inflamed.

I think his blood pannel looks much better: The Alb/Glob ration has gone from .44 back in July to .9. Which I think means no longer consistent with FIP. They key change is the alb which in July was 2.2 and now is 4.4. The glob hasn't changed much, its gone from 5.0 to 4.9.

There are some parameters that are really high but Dr. Harrison (the internal medicine vet was pleased. Marlene I would love to get your thoughts on it....

Bets wishes to everyone,

Cassie

Tomtens blood panel

CHEM 21 with COMPREHENSIVE CBC : CHEM 21 (1272)
Test Result Reference Range Low Normal High

ALK. PHOSPHATASE 6 0 - 62 U/L

ALT (SGPT) 35 28 - 100 U/L

AST (SGOT) 30 5 - 55 U/L

ALBUMIN 4.4 2.3 - 3.9 g/dL HIGH

TOTAL PROTEIN 9.3 5.9 - 8.5 g/dL HIGH

GLOBULIN 4.9 3.0 - 5.6 g/dL

TOTAL BILIRUBIN 0.0 0.0 - 0.4 mg/dL

DIRECT BILIRUBIN 0.0 0.0 - 0.2 mg/dL

BUN 37 15 - 34 mg/dL HIGH

CREATININE 1.2 0.8 - 2.3 mg/dL

CHOLESTEROL 142 82 - 218 mg/dL

GLUCOSE 114 70 - 150 mg/dL

CALCIUM 11.8 1
8.2 - 11.8 mg/dL

PHOSPHORUS 4.2 3.0 - 7.0 mg/dL

CHLORIDE 118 111 - 125 mEq/L

POTASSIUM 3.7 3.9 - 5.3 mEq/L LOW

SODIUM 157 147 - 156 mEq/L HIGH

A/G RATIO 0.9 0.4 - 0.8 HIGH

B/C RATIO 30.8 HIGH
INDIRECT BILIRUBIN 0.0 0 - 0.3 mg/dL

NA/K RATIO 42
HEMOLYSIS INDEX N 2

LIPEMIA INDEX N 3

Comments:
1. RESULT VERIFIED BY REPEAT ANALYSIS
2. Index of N,+,++ exhibits no significant effect on chemistry values.
3. Index of N,+,++ exhibits no significant effect on chemistry values.

CHEM 21 with COMPREHENSIVE CBC : CBC COMPREHENSIVE (1272)
Test Result Reference Range Low Normal High

WBC 6.3 4.2 - 15.6 K/uL

RBC 8.07 6.0 - 10.0 M/uL

HGB 12.8 9.5 - 15 g/dL

HCT 39.7 29 - 45 %

MCV 49 41 - 58 fL

MCH 15.9 11.0 - 17.5 pg

MCHC 32.2 29 - 36 g/dL

% RETICULOCYTE 0.1 %
RETICULOCYTE 8 3 - 50 K/uL

NEUTROPHILSEG 58.8 35 - 75 %

LYMPHOCYTES 30.5 20 - 55 %

MONOCYTES 5.0 1 - 4 % HIGH

EOSINOPHIL 5.4 2 - 12 %

BASOPHIL 0.3 0 - 1 %

AUTO PLATELET 192 170 - 600 K/uL

ANISOCYTOSIS SLIGHT
REMARKS SLIDE REVIEWED MICROSCOPICALLY.

ABSOLUTE NEUTROPHILSEG 3704 2500 - 12500 /uL

ABSOLUTE LYMPHOCYTE 1922 1500 - 7000 /uL

ABSOLUTE MONOCYTE 315 0 - 850 /uL

ABSOLUTE EOSINOPHIL 340 0 - 1500 /uL

ABSOLUTE BASOPHIL 19 0 - 100 /uL
_______________________________

14 December  2012

I love CR!!!! Cure is better but I love Clinical Response.

His total protein has gone up from 7.2 in July to 9.3. His Calcium has also gone up from 7.7 to 11.8.

He is eating well. Tomten has always lived to eat. I notice he sometimes now eats smaller amounts and then goes back and finishes it off 15 minutes later. In July his weight fell to 8.0 lbs he is up to 9.6 lbs.

Unfortunately he is addicted to fancy feast cat food which I fear may not be the most healthy but per Dr. Addie's recco I am supplementing it with a teaspoon a day of either Applepaws chicken, Tuna, Salmon. And he is getting raw steak 3 times a week. (Which he loves!!!) Makes up for the injections which he is increasingly getting more agitated about.

I will keep you posted on the scan in January.

For everyone who is new to the site and feeling hopeless (that was me in July- after all this was his second diagnosis of FIP- the first being a misdiagnosis when he was a kitten and actually had herpes. And I figured he couldn't get lucky twice and this was it). Hang in there! There is hope. Every day I have with Tom is a gift. I don't know how many we will have but we all treasure each day we have with our goofy fur ball and his brother.

Thanks to everyone for your continued support!

Cassie
__________________________________

22 September 2012

Subject: [FIPCatSupport] Update on Tomten- still doing well

Hi Everyone,  Its been a while since I posted. I contacted Dr. Addie and she agreed to consult with Dr. Harrison to see if Tomten really has or had fip and if he does to give us some advice on how to manage him since he is doing so well on the feline interferon. Now I am just waiting for the two to connect. Knock on wood he continues to do well. Went for a walk on his leash today outside and he was in kitty bliss!We are so grateful to still have him with us.

Dr.Addie was extremely helpful she suggested we immedietly take him off the L-lysine paste he has been taking for herpes since he was a kitten. Apparently, it interferes with the L'argine uptake. She also recommended we add raw red meat to his diet which Dr. Harrison is open to. So he is now getting chopped steak everyday and canned salmon from COSTCO. The steak is expensive but compared to the feline interferon a relative bargain! I also just ordered some applaws from amazon.com. Hopefully they will like it. His brother is super finkly and they really love their fancy feast but I am increasingly concerned I am feeding them yummy junk food. So we will see how it goes with the applaws.

Tomten is doing great but he is losing patience with us jabbing him every week. Upsetting for me as my once "velcro cat" is now nervous every time I pick him up that he is going to get jabbed. So hard because we can't explain it may be whats keeping him alive. But that being said the weather today was amazing and he loved going out for a walk with his brother.

One super goofy FIP moment is the family has taken to singing to Tomten and his brother Gizmo every night the "Kill the virus song" Modeled after Elmer Fudd's of bugs bunny fame "kill the wabbit song". I don't know that its helping but makes us all laugh and that seems to make the cats happy.

best thoughts to everyone, Cassie

14 January 2013 - click here for Tomtens update Great News!