COVID19 in Cats - the Ivermectin treatment

I just thought i'd bring this to your attention in case the authorities ever decide to start freaking out about pets transmitting covid19 . We have seen several cases expressed in the news for companion animals and the culling of mink in the netherlands. But the researchers are still dancing around trying not to alarm anyone. China led the studies with cats in april. Cats are quarantined and swabbed in covid positive households in hongkong. 

Here's the update from Dr Niels C Pedersen on the situation - i think he's got it backwards and we should urgently hose down the companion animal reservoir of coronaviruses. Healthy companion animals make more sense surely than sickly ones even if we aren't eating them! ( i would hate to see a FIP like illness appear in humans! )

Dear Veterinarians, cat owners and public: I am being increasingly questioned about the relationship of GS-441524 and a very promising treatment for Covid-19, Remdesivir.  GS-441524 is the biologically active component of Remdesivir and has been widely used around the world to safely and effectively cure cats of feline infectious peritonitis (FIP) for over 18 months. FIP is a common and highly fatal coronavirus disease of cats. GS-441424 and Remdesivir are almost identical drugs. Remdesivir is the form of GS-441424 that Gilead Sciences has chosen to use in humans for COVID-19 and is now in clinical trials in China, USA and several other countries. Remdesivir is what is known as a prodrug. A prodrug is altered by infected cells to yield the active ingredient, which in this case is basically GS-441524 with the addition of one phosphate group (i.e., GS-5734).  Gilead scientists slightly altered GS-5734 to protect the added phosphate group and allow absorption into cells. This form of GS-441524 is what is known as Remdesivir. Once in the cells, cellular enzymes remove the protection to yield  GS-5734. GS-5734 is further activated by the addition of two more phosphates in the cells to the triphosphate form of GS-441524. This is the molecule that inhibits the production of viral RNA.  We chose to use GS-441524 for treatment of the coronavirus disease FIP because it had identical antiviral properties to Remdesivir and at the time was not under consideration by Gilead Sciences for use in humans. GS-441524 is also much cheaper to make than Remdesivir. Therefore, there was no apparent conflict with using one form for cats and another form for humans.  However, Gilead came to believe that our cat research would interfere with their ability to get Remdesivir approved for humans and refused to grant animal rights for GS-441524.  This refusal, coupled with the desperate need around the world for the treatment of FIP, led to a Chinese black market for GS-441524.  FIP is also a significant problem in pet cats in China, and Chinese cat owners were even more desperate for a treatment for FIP than owners in other countries. The first papers describing GS-441524 treatment of cats with FIP were published in 2018 and 2019 and thousands of cats have been treated since then. In spite of this experience, the medical profession, including researchers, have been seemingly unaware of the use of GS-441524 for a coronavirus disease of cats and its relationship to Remdesivir. Veterinarians also have considerable experience with coronaviruses, coronavirus diseases, and coronavirus vaccines for swine, calves and poultry that has gone unappreciated. Pet ferrets also suffer a severe FIP-like disease caused by their own species of coronavirus.What will happen to supplies of GS-441524 for cats if Remdesivir is proven to be safe and effective as a treatment for Covid-19?  GS-441524 is the first critical step in the production of Remdesivir and it is logical to assume that there will be a competition between cats and humans for it.  On a positive note, world wide approval for Remdesivir may also help change minds against granting animal rights for GS-441524. If approved for human use, Remdesivir, if not GS-441524, would become "legally" available through veterinarians.  However, the safety and efficacy of Remdesivir for FIP has not been established. 

-Niels C. Pedersen, DVM, PhD, School of Veterinary Medicine, UC Davis. via https://www.zenbycat.org/blog/connection-between-fip-and-covid19 

I'm betting its easy to go from cat to human via the litter tray. So I implore you to have some backup ideas ready! Dr Borody outlines how to treat COVID19 in humans with Ivermectin - a worm medicine available over the counter for livestock.

https://www.bloomberg.com/press-releases/2020-08-19/ivermectin-triple-therapy-protocol-for-covid-19-to-australian-gp 

http://covexit.com/we-know-its-curable-its-easier-than-treating-the-flu-professor-thomas-borody/ 

Ivermectin doesn't seem to be available easily online for cats and dogs in australia that i am aware of.

So for cats a simple solution may be to just use Selamectin (a synthetic ivermectin) as post exposure prophylaxis "Revolution" is the brand name.

there's a fatal COVID19 case in a 4month old birman kitten outlined here https://www.biorxiv.org/content/10.1101/2020.09.23.309948v1.full 

Sounds depressingly familiar to anyone who has had a cat with FIP ( feline infectious peritonitis)  caused by a coronavirus in cats . It's oral fecal and so rips through crowded rescue shelters, mild disease in most cats but ragdolls and birmans are inbred and genetically appear susceptible to the FIP coronavirus. FIP is mostly seen in kittens due to immune system being immature. FIP appears to respond readily to the active metabolite of remdesivir - gs441524 (GS441 for short) It has been available online for some time via Chinese manufacturers who ignore Gilead's patent. The timing of being able to get this was just so 'interesting'. One of the stores which sells it online is mutian.us I became aware that it was available early this year and posted "happy new year"