Pharoah tries stemcells for FIP and the cure for FIP is found!

One success story at a time

With FIP there is no point being conservative except for the sake of the cat's comfort. So it was no surprise to hear that yet another innovative therapy is being tried - adipose stemcell therapy for dry FIP. The cat is called Pharoah and his vet is Ed Pattison of City Vets, Exeter UK https://www.facebook.com/cityvets/photos/a.128542133823284.22418.128403317170499/957763074234515/

But how interesting is this - the vet who pioneered the use of adipose stemcells for arthritis in dogs in australia, Simon Craig, was the same chap who cured Dusty of wet FIP - see survivor's page

and how dull and unsexy is this - Hip arthritis in dogs by the way you can simply prevent with adequate vitamin C and a proper diet.
http://oneradionetwork.com/health/dr-r-geoffrey-broderick-world-renowned-veterinarian/

Dr Belfield has the word on vitamin c in animals and was kind enough to answer my emails when Mishka was diagnosed. he did try it for FIP of course and it was the one thing he had no success with after it was established :( That's what we are up against.
I have NO DOUBT this is the same with FIP - we can prevent it  simply - no rocket stemcell science required and finally someone in authority is brave enough to say it 

"The best treatment for FIP is not to get it in the first place: if you are going to buy a pedigree kitten, make sure your Vet sends a blood sample to the University of Glasgow Veterinary Diagnostic Services to get a certificate saying that the kitten tested negative for feline coronavirus (FCoV) antibodies: we need to put consumer pressure on bad breeders and reward good ones." Dr Dianne Addie rocks! http://www.theexeterdaily.co.uk/news/local-news/exeter-vets-pioneer-stem-cell-treatment

- see prevention page

• stop inbreeding 
• stop crowding 
• stop malnourishment of starvation and stop feeding COOKED CRAP & KIBBLE to cats - they weren't designed to eat cereal; they are not birds.

Tigger

"I'm so happy I could bounce!" ~ Tigger

This is a story I got from one of the FIP yahoo groups. It has stayed in the drafts folder of this blog for over a year. I didn't manage to contact Tigger's mum for more details, a picture and so on. Post is copied verbatim as I expect Tigger's mum wants the story out there. So sadly I don't have details of diagnosis, no bloodwork - that's a caveat, it may not be FIP but it's hard to think of what else could have made him so sick for 6 weeks; my notes say wet FIP.  I can see the precipitating immune suppressing causes are pretty common ones. The move was big one as I recall; I think Tigger had to take a plane ride and was received at the other end unwell. He is a little older than usual. Most importantly Tigger's successful treatment has commonalities with other survivors - antibiotics combined with IV fluids and an immune stimulant - in this case interferon ( i think probably it is feline interferon since this cat is in Europe. ) special food (again wish I knew the details!) and intense daily attention.

Hi. I have a rambunctious male 5 year old cat. His name is Tigger. 5 months ago, I moved to Turkey. He had a shot for Luekemia (sp prob wrong) Anyway BAD idea. Don't ever get your cat a shot for this without getting him tested for the corona virus. I'm not sure if I spelled that right either but it's easy enough for you to google.

Anyway, the move and shot sent him into full blown FIP. His eyes were rolling to the back of his head, sky high fever, skin and bones, boy did I thought he was a goner. We started interferon and vitamins, antibiotics and Iv every day for a month and a half. Each day I spent 2-3 hours at the vet. 5 months later, he is alive and fat and happy. Each day I give him 2 vitamins. One in the morning and one at night. And they have garlic in them, yes, garlic.

If you make a serious commitment to keep your cat alive, I believe you have a pretty good shot of beating this with the help of interferon. I also give him food for sensitive systems and NO treats!! TReats do not help any cat. I have a second cat that seems to be fine and probably live to be 20. Tigger is living on borrowed time but I treasure ever extra moment. I also keep their cat box VERY clean. 2ce a day I clean it. My heart goes out to all owners with fip cats. It's heart wrenching, I know.

My other thought, a year of case history reviews later, is that I feel vets are not paying enough attention to fluid and salt (electrolyte) managment in FIP cats. Sick inapetant cats are easily dehydrated as they are desert animals designed to get most of their fluids from freshly killed prey. Vets seem to devote all the owner's resources to diagnostic gymnastics while their patient slips away from under their noses. Any reasonably sick human wheeled into an ER would be instantly hooked to an IV while this is worked out.
Also on the home front I doubt this cat was left to waste his remaining energy dragging himself to a litterbox too far, up a flight of stairs to the bedroom or being needlessly stressed by a bath (this is not sarcasm - I do actually know of someone who went to the trouble of getting PI then bathed their FIP cat. Predictably it took a downhill turn from there and is not listed on my survivors log.)

picture by felicia ruiyi - deviantart

Noms

 

Food does not come in a pyramid for Mishka, just - Noms or Antinoms. (nom = sound cat makes head down in plate of  yummy food "nom nom nom") Strangely curcumin extract. ground eggshell, the appallingly black fulvic minerals, and Dr Wheatgrass extract which all cause my human child to gag are acceptable cat condiments.

Noms - fish, roast chicken, roast lamb, mashed pumpkin, Kraft cheeseslices,whey powder, raw egg yolk, grass and wheatgrass even though this sometimes makes her gag or even throw up (the kitty equivalent of alcohol? so nom i don't care about hangovers?)

Antinoms -raw meat, beef, ascorbic acid, spirulina, glandular, Hills a/d, chicken liver, beef liver, liver powder, liver flavouring, did i mention liver?

Tish's list is of course the complete reverse - except for spirulina - evil green pond sludge which no one except me thinks is acceptable. Mishka will reject the entire plate of food if it contains a particle of antinoms the size of a nailhead.

So of course a raw diet is just what the doctors Addie (FIP research), Lipkin (virus hunter) Kremer (HIV expert below) ordered for our purebred princess. Ziwipeak (airdried meat - fits into the definition of a raw diet as it avoids high/low temp processing ) and raw eggyolk are the closest she gets to a primal diet.

The experts mention L carnitine which is the one amino acid I thought a carnivore would have trouble being deficient in. Turns out we can cook the nutrition out of anything; 

" dog and cat foods are extremely low in free L- Carnitine levels as compared with that found in raw ground beef. Most pets are maintained strictly on commercial pet food diets and are thus kept chronically deficient in L- Carnitine. " Lack of Carnitine causes muscle weakness including heart disease. http://meowmeowmom.wordpress.com/2008/05/05/the-carnitine-conundrum/

Carnitine is easy to get as a powder - but the acidic form has a sour taste which cats loathe. If you cannot pill a cat who won't eat raw try QUINICARN chicken flavoured powder Supplement For Dogs & Cats "Supports Body's Defense Against Physiological and Metabolic Stress" cat dose 250 mg daily

Kremer's Nontoxic AIDS Therapy and Prevention

I am slowly reading a scholarly work on HIV/AIDS by Heinrich Kremer, 'The Silent Revolution of the AIDS- and Cancer-Medicine' A complete summary of the book is available online - http://www.aliveandwellsf.org/kremer/ it has the lowdown on what kicks a system from th1 to th2 and how to prevent that; makes so much sense, like a universal theory of disease. I cut to the healing section yesterday. it has some reccomendations which may translate well to cats. the key is to avoid oxidative stress and support the glutathione levels in the body; FIP cats have low plasma glutathione. it is why dr addie wants us to add arginine to the diet for FIP as a couple of teaspoons of raw red meat a week - again i'm researching precise dose levels for supplemental powders as Mishka won't eat raw ( so much cheaper and easier if she would just eat the meat raw! Amino acid supplementation is fiddly - stuffing up ratios causes much more harm than good.)

NAcetylCysteine NAC another key antioxidant in the glutathione chain may also be useful both as treatment and preventative.
"N-acetylcysteine (NAC) is a chemically modified form of the dietary amino acid cysteine. Cysteine and NAC contain sulphur, which is key to protecting the body from damage by oxidation. Other sulphur containing antioxidants include alpha-lipoic acid and glutathione. Glutathione levels are considered the most reliable indicator of the body's resistance to oxidation, and NAC plays a role in glutathione metabolism. While touted by many supplement manufacturers as a precursor to glutathione, NAC probably has more of a sparing effect. That is, it neutralises oxidants in place of glutathione, allowing glutathione levels to be maintained." http://www.manorvets.co.uk/pet-sub-sub/972-n-acetylcysteine/

Where iz my cheezeburger?

 " A great many things in my life would be different if only I could open the door to the refrigerator. "~ Henri, le chat noir

 

 Grains and carnivores - not a happy mix

It is nice to have Mishka back to normal - hunting around the house in the wee hours for snacks ... bang bang bang at 4 am opening cupboards, finding her in a pile of kibble ....

oh crap - waiting for the sound of puking

She was vomiting again on tuesday evening / wed morning. Perhaps it was a bit of plastic from chomping into the loaf of fruit bread on the bench, or the bread itself.  Thankfully settled by midday but for many hours I thought it was all over though she is stronger; still playing with me after 4 chucks! took five to take her down a bit, and she remained well hydrated. Previously one or two chucks made her a limp fur rag. She was examined and cleared by our vet for continued treatment, so drained again wed pm and perked up straight way as usual - so we put it down to scoffing kibble accidentally left out for the other cat on top of the illicit snacks. We are not serving even a  mouthful of this junk food even as a treat anymore though she does miss it since Friskies Indoor was all she ever ate when she came to us.

Mishka wasn't particularly fippy belly leading up to the vomiting so it caught me by surprise. Might be magical thinking but let's pretend the fluid is slowing down marginally. After a week we only drained 465 mls. The time before we took off that much after only five days. No hairball has come up, and also no grass yet even though she has also scoffed her nommy new wheatgrass today which astonishingly seemed to make her feel better almost immediately.

Firstly i stopped the curcumin and pentoxifylline cream since they can both upset the tummy with no difference in Mishka's constitution except she is happier ( the pentoxi cream was was getting increasingly unsettling applied even just twice daily instead of the required three. i wasn't going to renew the prescription as it hasn't made huge inroads into her disease for the emotional cost - just tried replacing it with curcumin as the anti-inflammatory. We haven't missed the prednisolone.

Curcumin extract suggested by a friend was originally rejected because i thought it would be hard to dose ( not true ~ she likes the flavour or ignores it but it stains fur pink! ) and I have read it may be immune suppressive although possibly in away that is ok For starters it hammers the TH1 and TH2 systems even handedly  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810449/ 
Too many long words - waiting on comment by Dr Norris. We can't get Thorne brand Curcuvet in australia but herbs of gold sell an easy to get product containing the same bioavailable Meriva extract Thorne uses.

And still waaaiting for the customs clearance to get PI - come on Santa!

Lessons from Dr. Lipkin

"SARS was contained not because of a drug or vaccine but because we identified people who were infected or at risk, and we isolated them." ~ Prof Ian Lipkin MD

"When DISCOVER features editor Pamela Weintraub interviewed Lipkin last year, his dog, Koprowski was desperately sick. Lipkin had a treatment plan: not an antiviral drug or chemotherapy, but red meat. “It has antibiotics, it has growth hormone, it has everything"
Ian Lipkin is a virus hunter who was instrumental in helping China get control of SARS beginning with easy low tech things like soap and water for handwashing. He treated one of the first cases of AIDS successfully for a while with the new but existing technique of plasmapharesis to remove the antibody complexes that were causing his patients neurological symptoms.

Let's follow Lipkins lead and treat FIP with these things. Raw meat Mishka wont eat so until i can get hold of raw goats milk shes happily eating a kitty powershake - undenatured whey and colostrum powders, a teaspoon of each mixed with a teasoon of water daily, and raw egg yolk - yum!

FIP shares some similarities with SARS they are both corona viruses, and AIDS a disease of marked immune dysfunction.

Here's Mishka - Half the cat she was. She's leaking about 100 mls of fluid and protein a day into her peritoneum from damaged blood vessels - if we opened her belly up we would see little lumps called granulomas everwhere as the body tries unsuccessfully to destroy diseased cells that are nestled in the tissues like splinters. Collateral damage inflames the blood vessels - so far everything we have tried has not stopped this.
I have to wonder if plasmapharesis would have any success - UC Davis uses it for dogs with myesthenia gravis just as it is used in humans with this disease which inspired Lipkins AIDS treatment.